منابع مشابه
ECM signals ECM degradation
W hen Caroline Damsky moved her lab to the University of California, San Francisco, in 1985, she knew she would have an instant colleague in Zena Werb. There was a natural connection between their work. That connection would be refl ected in their discoveries, which delineated an integrin-mediated pathway from the extracellular matrix (ECM) outside the cell to the internal, gene-expressing life...
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Cardiovascular diseases (CVD) are a leading death cause in developed countries (1 of every 3 deaths in the United States in 2008) [1]. Changes in diet and habits are causing CVD to become major mortality pathologies in developing countries too [2] (they are already responsible for a 30% of the world deaths). This group of diseases constitutes a great burden for the national health systems, cons...
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ago is within the realm of possibility today, and various tissue engineering products are already being applied in clinical practice. Spectacular developments include the generation of induced pluripotent stem cells (Takahashi and Yamanaka, 2006), a beating heart in a petri dish (Jakab et al., 2008), the first successful transplantation of a tissue-engineered trachea (Macchiarini et al., 2008),...
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The natural extracellular matrix (ECM), with its multitude of evolved cell-instructive and cell-responsive properties, provides inspiration and guidelines for the design of engineered biomaterials. One strategy to create ECM-mimetic materials is the modular design of protein-based engineered ECM (eECM) scaffolds. This modular design strategy involves combining multiple protein domains with diff...
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ژورنال
عنوان ژورنال: Materials Today
سال: 2012
ISSN: 1369-7021
DOI: 10.1016/s1369-7021(12)70197-9